Associate Professor Alexander Dobrovic PhD leads the Translational Genomics and Epigenomics Laboratory at the Olivia Newton-John Cancer Centre in Melbourne.
In his previous lab, he developed high resolution melting assays for DNA methylation and for the detection of KRAS, BRAF and TP53 mutations that entered routine diagnostics. His current lab continues the focus on personalized medicine including developing clinically relevant innovative diagnostic methodologies. His lab has recently been accredited for DNA methylation assays (BRCA1, MLH1 and MGMT) and liquid biopsy assays for BRAF and EGFR mutations using droplet digital PCR. His major research interests are in the emerging fields including circulating tumour DNA, and constitutional BRCA1 methylation in breast and ovarian cancer predisposition. He is a chief investigator of several consortia funded by the Victorian Cancer Agency, Cancer Australia and the Australian National Breast Cancer Foundation Collaborative Research Program.